A Place for Hope

The immune system uses chemical called cytokines to bring immune cells to areas of infection or cancer and to stimulate this immune cells to fight these threats.  Dr. Daud and his colleagues have developed a unique approach to fighting melanoma by making the melanoma tumors themselves generate one of the cytokines that stimulates immune response.  This is done by injecting a small amount of DNA for the cytokine into a melanoma tumor on the skin and then using electricity to get the cancer cells to absorb this DNA.  After that, the tumors will make the cytokines themselves essentially telling the immune system to "come and get me."  This approach has lead to improvents in melanoma throughout the body in some patients, even in tumors that were not treated directly  We are currently enrolling patients with unresectable melanoma of the skin and lymph nodes into a clinical trial of plasmid-IL12 with electroporation at UCSF.  

Key Inclusion / Exclusion Criteria:

  • Unresectable stage III or stage IV melanoma that has not spread beyond the skin and lymph nodes
  • No pacemaker or other implantable electronic devices

Contact:  Dr. Adil Daud, adaud@medicine.ucsf.edu

Clinicaltrials.gov link: http://www.clinicaltrials.gov/ct2/show/NCT01502293