Clinical Trials

Currently Enrolling at UCSF:

A Clinical Study of V940 and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/​INTerpath-012)
NCT06961006
Sponsor:    Merck Sharp & Dohme LLC
PI:    Adil Daud, MD

A First-In Human (FIH) Trial to Find Out if REGN10597 is Safe and How Well it Works for Adult Participants With Advanced Solid Organ Malignancies
NCT06413680
Sponsor:    Regeneron Pharmaceuticals
PI:    Adil Daud, MD

A Phase 1B/​2 Study of RP1 in Solid Organ Transplant Patients With Advanced Cutaneous Malignancies (ARTACUS)
NCT04349436
Sponsor:    Replimune Inc.
PI:    Katy Tsai, MD

A Study of IBI363 in Subjects with Advanced Solid Malignancies
NCT06281678 
Sponsor:    Innovent Biologics
PI:    Katy Tsai, MD

A Study of NX-1607 in Adults With Advanced Malignancies
NCT05107674    
Sponsor:    Nurix Therapeutics, Inc.
PI:    Pamela Munster, MD

A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With NRAS-mutant Melanoma (SEACRAFT-2)
NCT06346067
Sponsor:    Erasca, Inc.
PI:    Adil Daud, MD

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations
NCT05503797
Sponsor:    Fore Biotherapeutics
    
A Study to Evaluate KIN-2787 in Participants With BRAF and/​or NRAS Mutation Positive Solid Tumors
NCT04913285
Sponsor:    Pierre Fabre Medicament
PI:    Adil Daud, MD

A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors
NCT06326411
Sponsor:    Nested Therapeutics, Inc
PI:    Varun Monga, MD

A Study to Learn About the Study Medicine Called PF-08046031 in Advanced Melanoma and Other Solid Tumors
NCT06799533
Sponsor:    Pfizer
PI:    Adil Daud, MD

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
NCT06246916
Sponsor:    Regeneron Pharmaceuticals 
PI:    Katy Tsai, MD

A Trial to Learn if Fianlimab and Cemiplimab Are Safe and Work Better Than Anti-PD1 Alone in Adult Participants With Resectable Stage 3 or 4 Melanoma
NCT06190951
Sponsor:    Replimune Inc.
PI:    Adil Daud, MD

Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanoma
NCT04598009
Sponsor:    Pfizer
PI:    Katy Tsai, MD

IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma
NCT05987332
Sponsor:    IDEAYA Biosciences
PI:    Katy Tsai, MD

IFx-Hu2.0 As An Adjunctive Therapy To Pembrolizumab In Advanced Or Metastatic Merkel Cell Carcinoma (MCC)
NCT06947928
Sponsor:    TuHURA Biosciences, Inc.
PI:    Adil Daud, MD

NBTXR3 Activated by Radiotherapy for Patients with Advanced Cancers Treated with an Anti-PD-1 Therapy
NCT03589339
Sponsor:    Nanobiotix
PI:    Jason Chan, MD

Peripheral T Cell Determinants of Response and Resistance to Pembrolizumab in Melanoma
NCT05105100
Sponsor:    University of California, San Francisco
PI:    Adil Daud, MD

Safety and Tolerability Study of GIM-122 in Subjects With Advanced Solid Malignancies
NCT06028074
Sponsor:    Georgiamune Inc.
PI:    Katy Tsai, MD

Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors
NCT06425926
Sponsor:    Georgiamune Inc.
PI:    Katy Tsai, MD

Study of DCC-3084 in Participants With Advanced Malignancies Driven by the Mitogen-Activated Protein Kinase (MAPK) Pathway
NCT06287463
Sponsor:    Deciphera Pharmaceuticals
PI:    Rahul Aggarwal, MD

Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors
NCT05533697
Sponsor:    ModernaTX, Inc.
PI:    Adil Daud, MD

Study of RP1 Monotherapy and RP1 in Combination With Nivolumab
NCT03767348
Sponsor:    Replimune Inc.
PI:    Katy Tsai, MD

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
NCT04851119
Sponsor:    Children's Oncology Group
PI:    Kieuhoa T. Vo, MD

Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery
NCT05111574
Sponsor:    National Cancer Institute (NCI)
PI:    Katy Tsai, MD

VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs (IGNYTE-3)
NCT06264180
Sponsor:    Replimune Inc.
PI:    Katy Tsai, MD